A study slated for publication in the Journal of Clinical Endocrinology & Metabolism reveals that higher levels of perfluorocarbons (PFCs) in the body are associated with increased odds of having experienced menopause at a younger age. Women with high levels of PFCs also have significantly lower estrogen levels.
“The current study is the largest ever to be done on the endocrine-disrupting effects of perfluorocarbons in human women,” notes lead author Sarah Knox, PhD. “Our data shows that after controlling for age, women of perimenopausal and menopausal age in this large population are more likely to have experienced menopause if they have higher serum concentrations of PFCs than their counterparts with lower levels.”
In this study of 25,957 women aged 18 to 65 years, researchers ascertained menopausal status of participants and then measured their serum concentration levels of PFCs and estradiol. They found that there was an association between PFC exposure, decreased estradiol and early menopause in women over age 42.
There was also an inverse association between PFC levels and estradiol in women of child bearing age but this association was not statistically significant.
JCEM – March 16, 2011